Efficient Algorithms for Immersive Audio Rendering Enhancement

Il rendering audio immersivo è il processo di creazione di un’esperienza sonora coinvolgente e realistica nello spazio 3D. Nei sistemi audio immersivi, le funzioni di trasferimento relative alla testa (head-related transfer functions, HRTFs) vengono utilizzate per la sintesi binaurale in cuffia poiché esprimono il modo in cui gli esseri umani localizzano una sorgente sonora. Possono essere introdotti algoritmi di interpolazione delle HRTF per ridurre il numero di punti di misura e per creare un movimento del suono affidabile. La riproduzione binaurale può essere eseguita anche dagli altoparlanti. Tuttavia, il coinvolgimento di due o più gli altoparlanti causa il problema del crosstalk. In questo caso, algoritmi di cancellazione del crosstalk (CTC) sono necessari per eliminare i segnali di interferenza indesiderati. In questa tesi, partendo da un'analisi comparativa di metodi di misura delle HRTF, viene proposto un sistema di rendering binaurale basato sull'interpolazione delle HRTF per applicazioni in tempo reale. Il metodo proposto mostra buone prestazioni rispetto a una tecnica di riferimento. L'algoritmo di interpolazione è anche applicato al rendering audio immersivo tramite altoparlanti, aggiungendo un algoritmo di cancellazione del crosstalk fisso, che considera l'ascoltatore in una posizione fissa. Inoltre, un sistema di cancellazione crosstalk adattivo, che include il tracciamento della testa dell'ascoltatore, è analizzato e implementato in tempo reale. Il CTC adattivo implementa una struttura in sottobande e risultati sperimentali dimostrano che un maggiore numero di bande migliora le prestazioni in termini di errore totale e tasso di convergenza. Il sistema di riproduzione e le caratteristiche dell'ambiente di ascolto possono influenzare le prestazioni a causa della loro risposta in frequenza non ideale. L'equalizzazione viene utilizzata per livellare le varie parti dello spettro di frequenze che compongono un segnale audio al fine di ottenere le caratteristiche sonore desiderate. L'equalizzazione può essere manuale, come nel caso dell'equalizzazione grafica, dove il guadagno di ogni banda di frequenza può essere modificato dall'utente, o automatica, la curva di equalizzazione è calcolata automaticamente dopo la misurazione della risposta impulsiva della stanza. L'equalizzazione della risposta ambientale può essere applicata anche ai sistemi multicanale, che utilizzano due o più altoparlanti e la zona di equalizzazione può essere ampliata misurando le risposte impulsive in diversi punti della zona di ascolto. In questa tesi, GEQ efficienti e un sistema adattativo di equalizzazione d'ambiente. In particolare, sono proposti e approfonditi tre equalizzatori grafici a basso costo computazionale e a fase lineare e quasi lineare. Gli esperimenti confermano l'efficacia degli equalizzatori proposti in termini di accuratezza, complessità computazionale e latenza. Successivamente, una struttura adattativa in sottobande è introdotta per lo sviluppo di un sistema di equalizzazione d'ambiente multicanale. I risultati sperimentali verificano l'efficienza dell'approccio in sottobande rispetto al caso a banda singola. Infine, viene presentata una rete crossover a fase lineare per sistemi multicanale, mostrando ottimi risultati in termini di risposta in ampiezza, bande di transizione, risposta polare e risposta in fase. I sistemi di controllo attivo del rumore (ANC) possono essere progettati per ridurre gli effetti dell'inquinamento acustico e possono essere utilizzati contemporaneamente a un sistema audio immersivo. L'ANC funziona creando un'onda sonora in opposizione di fase rispetto all'onda sonora in arrivo. Il livello sonoro complessivo viene così ridotto grazie all'interferenza distruttiva. Infine, questa tesi presenta un sistema ANC utilizzato per la riduzione del rumore. L’approccio proposto implementa una stima online del percorso secondario e si basa su filtri adattativi in sottobande applicati alla stima del percorso primario che mirano a migliorare le prestazioni dell’intero sistema. La struttura proposta garantisce un tasso di convergenza migliore rispetto all'algoritmo di riferimento.Immersive audio rendering is the process of creating an engaging and realistic sound experience in 3D space. In immersive audio systems, the head-related transfer functions (HRTFs) are used for binaural synthesis over headphones since they express how humans localize a sound source. HRTF interpolation algorithms can be introduced for reducing the number of measurement points and creating a reliable sound movement. Binaural reproduction can be also performed by loudspeakers. However, the involvement of two or more loudspeakers causes the problem of crosstalk. In this case, crosstalk cancellation (CTC) algorithms are needed to delete unwanted interference signals. In this thesis, starting from a comparative analysis of HRTF measurement techniques, a binaural rendering system based on HRTF interpolation is proposed and evaluated for real-time applications. The proposed method shows good performance in comparison with a reference technique. The interpolation algorithm is also applied for immersive audio rendering over loudspeakers, by adding a fixed crosstalk cancellation algorithm, which assumes that the listener is in a fixed position. In addition, an adaptive crosstalk cancellation system, which includes the tracking of the listener's head, is analyzed and a real-time implementation is presented. The adaptive CTC implements a subband structure and experimental results prove that a higher number of bands improves the performance in terms of total error and convergence rate. The reproduction system and the characteristics of the listening room may affect the performance due to their non-ideal frequency response. Audio equalization is used to adjust the balance of different audio frequencies in order to achieve desired sound characteristics. The equalization can be manual, such as in the case of graphic equalization, where the gain of each frequency band can be modified by the user, or automatic, where the equalization curve is automatically calculated after the room impulse response measurement. The room response equalization can be also applied to multichannel systems, which employ two or more loudspeakers, and the equalization zone can be enlarged by measuring the impulse responses in different points of the listening zone. In this thesis, efficient graphic equalizers (GEQs), and an adaptive room response equalization system are presented. In particular, three low-complexity linear- and quasi-linear-phase graphic equalizers are proposed and deeply examined. Experiments confirm the effectiveness of the proposed GEQs in terms of accuracy, computational complexity, and latency. Successively, a subband adaptive structure is introduced for the development of a multichannel and multiple positions room response equalizer. Experimental results verify the effectiveness of the subband approach in comparison with the single-band case. Finally, a linear-phase crossover network is presented for multichannel systems, showing great results in terms of magnitude flatness, cutoff rates, polar diagram, and phase response. Active noise control (ANC) systems can be designed to reduce the effects of noise pollution and can be used simultaneously with an immersive audio system. The ANC works by creating a sound wave that has an opposite phase with respect to the sound wave of the unwanted noise. The additional sound wave creates destructive interference, which reduces the overall sound level. Finally, this thesis presents an ANC system used for noise reduction. The proposed approach implements an online secondary path estimation and is based on cross-update adaptive filters applied to the primary path estimation that aim at improving the performance of the whole system. The proposed structure allows for a better convergence rate in comparison with a reference algorithm

HRTFs Measurement Based on Periodic Sequences Robust towards Nonlinearities in Automotive Audio

The head related transfer functions (HRTFs) represent the acoustic path transfer functions between sound sources in 3D space and the listener’s ear. They are used to create immersive audio scenarios or to subjectively evaluate sound systems according to a human-centric point of view. Cars are nowadays the most popular audio listening environment and the use of HRTFs in automotive audio has recently attracted the attention of researchers. In this context, the paper proposes a measurement method for HRTFs based on perfect or orthogonal periodic sequences. The proposed measurement method ensures robustness towards the nonlinearities that may affect the measurement system. The experimental results considering both an emulated scenario and real measurements in a controlled environment illustrate the effectiveness of the approach and compare the proposed method with other popular approaches

Traditional knowledge on ethno-veterinary and fodder plants in South Angola: an ethnobotanic field survey in Mopane woodlands in Bibala, Namibe province

Livestock is a critical resource to improve income and household livelihoods in many rural areas. To date, very few studies have investigated farmers’ local knowledge on plants used in managing animal health and welfare in Angolan Mopane woodland. This is a very dry ecosystem where animal husbandry (mostly cattle and goats breeding) is highly widespread and is often the main form of subsidence, greatly contributing to local communities food security, especially in periods of resources shortage. An ethnobotanical research project was carried out in Bibala (Namibe province – Angola) in 2010 – 2012, in order to collect information on different traditional uses of plants, involving an interviewed sample of 66 informants. Fifty-eight of them (87.9%) listed a total of 39 species used as ethno-veterinary and/or fodder plants. Ten ethno-veterinary species (28 citations) were reported by 20 informants as used to treat diseases commonly affecting animals in the studied area, namely respiratory tract problems (Laphangium luteoalbum, Gyrocarpus americanus, Craibia brevicaudata subsp. baptistarum, Lepisanthes senegalensis, Ptaeroxylon obliquum, Ximenia americana) and skin diseases and wounds (Aloe littoralis, Blepharis sp., Ficus thonningii), or acting as a general tonic (Faidherbia albida). Thirty-four plants (235 citations) were cited by 58 informants as fodder. In this category of use, the most cited species were Terminalia prunioides (30 citations), Faidherbia albida (28 citations) and Spirostachys africana (21 citations). Our study shows that communities living in South Angola Mopane woodlands still retain a valuable traditional knowledge about plants used to maintain animal health and welfare. This body of knowledge and related skills can play a crucial role in the resilience of livestock systems facing present environmental and socioeconomic changes

Proteomics Insights into Medullary Sponge Kidney Disease: Review of the Recent Results of an Italian Research Collaborative Network

Background: Medullary sponge kidney (MSK) disease is a rare and neglected congenital condition typically associated with nephrocalcinosis/nephrolithiasis, urinary concentration defects, and cystic anomalies in the precalyceal ducts that, although sporadic in the general population, is relatively frequent in renal stone formers. The physiopathologic mechanism associated with this disease is not fully understood, and omics technologies may help address this gap. Summary: The aim of this review was to provide an overview of the current state of the application of proteomics in the study of this rare disease. In particular, we focused on the results of our recent Italian collaborative studies that, analyzing the MSK whole and extracellular vesicle urinary content by mass spectrometry, have displayed the existence of a large and multifactorial MSK-associated biological machinery and identified some main regulatory biological elements able to discriminate patients affected by this rare disorder from those with idiopathic calcium nephrolithiasis and autosomal dominant polycystic kidney disease (including laminin subunit alpha 2, ficolin 1, mannan-binding lectin serine protease 2, complement component 4-binding protein β, sphingomyelin, ephrins). Key Messages: The application of omics technologies has provided new insights into the comprehension of the physiopathology of the MSK disease and identified novel potential diagnostic biomarkers that may replace in future expensive and invasive radiological tests (including CT) and select novel therapeutic targets potentially employable, whether validated in a large cohort of patients, in the daily clinical practice

Autoregressive Point-Processes as Latent State-Space Models: a Moment-Closure Approach to Fluctuations and Autocorrelations

Modeling and interpreting spike train data is a task of central importance in computational neuroscience, with significant translational implications. Two popular classes of data-driven models for this task are autoregressive Point Process Generalized Linear models (PPGLM) and latent State-Space models (SSM) with point-process observations. In this letter, we derive a mathematical connection between these two classes of models. By introducing an auxiliary history process, we represent exactly a PPGLM in terms of a latent, infinite dimensional dynamical system, which can then be mapped onto an SSM by basis function projections and moment closure. This representation provides a new perspective on widely used methods for modeling spike data, and also suggests novel algorithmic approaches to fitting such models. We illustrate our results on a phasic bursting neuron model, showing that our proposed approach provides an accurate and efficient way to capture neural dynamics

In vitro recapitulation of the site-specific editing (to wild-type) of mutant IDS mRNA transcripts, and the characterization of IDS protein translated from the edited mRNAs

The transfer of genomic information into the primary RNA sequence can be altered by RNA editing. We have previously shown that genomic variants can be RNA-edited to wild-type. The presence of distinct “edited” iduronate 2-sulfatase (IDS) mRNA transcripts ex vivo evidenced the correction of a nonsense and frameshift variant, respectively, in three unrelated Hunter syndrome patients. This phenomenon was confirmed in various patient samples by a variety of techniques, and was quantified by single-nucleotide primer extension. Western blotting also confirmed the presence of IDS protein similar in size to the wild-type. Since preliminary experimental evidence suggested that the “corrected” IDS proteins produced by the patients were similar in molecular weight and net charge to their wild-type counterparts, an in vitro system employing different cell types was established to recapitulate the site-specific editing of IDS RNA (uridine to cytidine conversion and uridine deletion), and to confirm the findings previously observed ex vivo in the three patients. In addition, confocal microscopy and flow cytometry analyses demonstrated the expression and lysosomal localization in HEK293 cells of GFP-labeled proteins translated from edited IDS mRNAs. Confocal high-content analysis of the two patients’ cells expressing wild-type or mutated IDS confirmed lysosomal localization and showed no accumulation in the Golgi or early endosomes

Toxoplasmosis in transplant recipients, Europe, 2010-2014

Transplantation activity is increasing, leading to a growing number of patients at risk for toxoplasmosis. We reviewed toxoplasmosis prevention practices, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe. We collected electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010-2014. Serologic pretransplant screening of allo-hematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. SOT recipients were systematically screened in 6 countries. Targeted anti-Toxoplasma chemoprophylaxis was heterogeneous. A total of 87 toxoplasmosis cases were recorded (58 allo-HSCTs, 29 SOTs). The 6-month survival rate was lower among Toxoplasma-seropositive recipients and among allo-hematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis remains associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management

The Influence of Listeners’ Mood on Equalization-Based Listening Experience

Using equalization to improve sound listening experience is a well-established topic among the audio society. Finding a general equalization curve is a difficult task because of spectral content influenced by the reproduction system (loudspeakers and room environment) and personal preference diversity. Listeners’ mood is said to be a factor that affects the individual equalization preference. In this study, the effect of a listener’s mood on equalization preference is tried to be investigated. Starting from an experiment with fifty-two listeners, considering five predefined equalization curves and a database of ten music excerpts, the relationship between listeners’ mood and preferred sound equalization has been studied. The main findings of this study showed that the “High-frequency boosting” equalization was the most preferred among participants. However, the “High-frequency boosting” preference of low-aroused people was slightly lower than the high aroused listeners, increasing the preference of the “Low-frequency boosting”

Linear-Phase Octave Graphic Equalizer

A computationally efficient octave-band graphic equalizer having a linear-phase response is introduced. The linear-phase graphic equalizer is useful in audio applications in which phase distortion is not tolerated, such as in multichannel equalization, parallel processing, phase compatibility of audio equipment, and crossover network design. The structure is based on the interpolated finite impulse response (IFIR) philosophy. The proposed octave-band graphic equalizer uses one prototype low-pass filter, which is a half-band FIR filter designed using the window method. Stretched versions of the prototype filter and its complementary high-pass filter implement all ten band filters needed. The graphic equalizer is realized in the parallel form, in which the outputs of all band filters, scaled with their individual command gain, are added to compute the equalized output signal. The command gains can be used directly as filter band gains. The number of operations needed per sample is only slightly more than that needed for the graphic equalizer based on minimum-phase recursive filters. A comparison with other implementation approaches demonstrates that the proposed structure requires 99% fewer operations than a high-order FIR filter. The proposed filter uses 39% fewer operations per sample than the fast Fourier transform--based filtering method and causes over 78% less latency